Acute myocardial infarction prevention, food diet supplements with organic lycopene as antioxidant to protect cardiovascular activities. Dietary food to prevent diseases as myocardial infarction, angina pectoris, stroke, heart failure, arrythmias.

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Cardiovascular Dietary Supplements wholesale production of heart care supplements to prevent angina pectoris, stroke, heart failure, arrythmias, acute myocardial infarction and other heart diseases with "Lycopne Diet Supplements" produced, according to the health international standards as antioxidant.

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SCIENTIFIC RESEARCHES ABOUT HEART HEALTH CARE DIETARY SUPPLEMENT There are many worldwide researches defining the high power of the organic components for human heart care supplements manufacturing industry. Scientific pubblications from University in Japan, USA, Italy, Australia,... confirms the quality and efficience of the Organic Lycopene to avoid main human diseases as Parkinson, Alzheimer disease, cancer and others. The scientific staff of Pierre Italy has used all of them as scientific reference to improve, to define our organic dietary supplements... APPLY FOR DISTRIBUTION

SCIENTIFIC RESEARCH TO CREATE LYCOMPLETE® - ITALIAN HEART CARE SUPPLEMENT MANUFACTURING

Rissanen T, Voutilainen S, Nyyssonen K, Salonen JT. - Research Institute of Public Health, University of Kuopio, Kuopio, Finland 70211. Lycopene, atherosclerosis, and coronary heart disease. Exp Biol Med (Maywood) 2002 Nov; 227(10):900-7 [File : 1ExpBiolMed2002.pdf]

Rao AV. - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood) 2002 Nov; 227(10):908-13 [File : 2ExpBiolMed2002.pdf]

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Voutilainen S, Nurmi T, Mursu J, Rissanen TH.- Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland. Carotenoids and Cardiovascular health.Am J Clin Nutr. 2006 Jun;83(6):1265-71. [File: 3AmJClinNutr2006.pdf]

Das S, Otani H, Maulik N, Das DK. Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. Lycopene, tomatoes, and coronary heart disease. Free Radic Res. 2005 Apr;39(4):449-55

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Edmond Kato Kabagambe, Jeremy Furtado, Ana Baylin, and Hannia Campos - Some Dietary and Adipose Tissue Carotenoids Are Associated with the Risk of Nonfatal Acute Myocardial Infarction in Costa Rica1,2 - J. Nutr. 135: 1763–1769, 2005. [File =142 JN 2005.pdf]

Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ - Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol 1997 Oct 15;146(8):618-626 [File : 6AmJEpid1997.pdf]

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Gerster H - Vitamin Research Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland. The potential role of lycopene for human health. J Am Coll Nutr 1997 Apr;16(2):109-126

Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Witteman JC - Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis 2000 Jan;148(1):49-56

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Arab L, Steck S - School of Public Health, University of North Carolina, Chapel Hill. Lycopene and cardiovascular disease. Am J Clin Nutr 2000 Jun;71(6 Suppl):1691S-5S; discussion 1696S-7SV [File : 9AmJClinNutr2000.pdf]

Rao AV, Agarwal S – Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada. Role of antioxidant lycopene in cancer and heart disease J Am Coll Nutr 2000 Oct;19(5):563-9 Review [ File : 10JAmCollNutr2000.pdf]

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Hsueh YM, Wu WL, Huang YL, Chiou HY, Tseng CH, Chen CJ - Department of Public Health, School of Medicine, Taipei Medical College, Taiwan, ROC. Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure. Atherosclerosis 1998 Dec;141(2):249-57

Agarwal S, Rao AV - Department of Nutritional Sciences, University of Toronto, ON, Canada Carotenoids and chronic diseases. Drug Metabol Drug Interact 2000;17(1-4):189-210

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Fuhrman B, Elis A, Aviram M - Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel. Hypocholesterolemic effect of lycopene and betacarotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem Biophys Res Commun 1997 Apr 28;233(3):658-662 . [File : 15BBRC1997.pdf]

Agarwal S, Rao AV - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ont. Tomato lycopene and its role in human health and chronic diseases. CMAJ 2000 Sep 19;163(6):739-44 [File : 16CMAJ2000.pdf]

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Rissanen T, Voutilainen S, Nyyssonen K, Salonen R, Salonen JT - Research Institute of Public Health, University of Kuopio, Finland, and Inner Savo Health Centre (J.T.S.), Finland. Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arterioscler Thromb Vasc Biol 2000 Dec;20(12):2677-81 [File : 21ArtThrVascBiol2000.pdf]

Paul Knekt; John Ritz; Mark A. Pereira; Eilis J O’Reilly; Katarina Augustsson; Gary E. Fraser; Uri Goldbourt; Berit L. Heitmann; Goran hallmans ; Simin Liu ; Pirjo Pietinen ; Donna Spiegelmam ; June Stevens ; Jarmo Vitarmo; Walter C. Willet; Eric B. Rimm; Alberto Ascherio; Antioxidant Vitamins and Coronary Heart Disease risk : a pooled analysis of 9 Cohorts. Am J. Clin Nutr. 2004; 80 : 1508-20 [File : 22AJCN2004.pdf]

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Dugas TR; Morel DW; Harrison EH - Impact of LDL carotenoid and alpha-tocopherol content on LDL oxidation by endothelial cells in culture - Journal of Lipid Research 1998, Vol 39, Iss 5, pp 999-1007 [File : 23 JlipRes1998.pdf]

Aviram M, Fuhrman B - Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel. LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: role of prooxidants vs. antioxidants. Mol Cell Biochem 1998 Nov;188(1-2):149-59

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Tertov VV, Sobenin IA, Kaplun VV, Orekhov AN - Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia - Antioxidant content in low density lipoprotein and lipoprotein oxidation in vivo and in vitro. Free Radic Res 1998 Aug;29(2):165-73

Plat J, van Onselen EN, van Heugten MM, Mensink RP - Department of Human Biology, Maastricht University, Maastricht, The Netherlands. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000 Sep;54(9):671-7

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Hoffmann J, Linseisen J, Riedl J, Wolfram G - Institute of Nutritional Sciences, Technical University of Munich. Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans. Eur J Nutr 1999 Dec;38(6):278-85

Cockey CD - Lycopene may contribute to heart health. AWHONN Lifelines 2002 Jun-Jul;6(3):206

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Carroll YL, Corridan BM, Morrissey PA - Department of Food Science and Technology, University College Cork, Ireland. Lipoprotein carotenoid profiles and the susceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. Eur J Clin Nutr 2000 Jun;54(6):500-7

Giugliano D - Dipartimento di Gerontologia, Geriatria e Malattie del Metabolismo, Seconda Universita di Napoli, Italy. Dietary antioxidants for cardiovascular prevention. Nutr Metab Cardiovasc Dis 2000 Feb;10(1):38-44

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Martin KR, Wu D, Meydani M - Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, 02111, Boston, MA, USA. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis 2000 Jun;150(2):265-74

Upritchard JE, Sutherland WH, Mann JI - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000 Jun;23(6):733-8

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Linseisen J, Hoffmann J, Riedl J, Wolfram G - Institute of Nutrition Science of the Technical University of Munich, Freising-Weihenstephan, Freising-Weihenstephan, D-85350, Germany - Effect of a Single Oral Dose of Antioxidant Mixture (Vitamin E, Carotenoids) on the Formation of Cholesterol Oxidation Products after ex vivo LDL Oxidation in Humans. Eur J Med Res 1998 Feb 21;3(1/2):5-12

Fuhrman B, Volkova N, Rosenblat M, Aviram M - Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid Redox Signal 2000 Fall;2(3):491-506

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Clinton, S. K.; Craft, N. E.; Degroff, V. L.; Hadley, C.W.; Harris, G. K.; Miller, B. C.; Schwartz, S. J The consumption of processed tomato products enhances plasma lycopene concentrations and reduces oxidative damage to lipoproteins in humans. FASEB Journal VOL. 15 NO. 4 March 7, 2001 PP. A297. March 31- April 04, 2001 Annual Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology 2001

Rissanen TH, Voutilainen S, Nyyssonen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT. Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr 2001 Jun;85(6):749-54

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Paran, Esther; Engelhard, Yehiel - Hypertension Unit, Soroka University medical Center, Beer Sheva, Israel Effect of tomato's lycopene on blood pressure, serum lipoproteins, plasma homocysteine and oxidative stress markers in grade I hypertensive patients. American Journal of Hypertension Vol. 14 N. 4 Part 2- April, 2001 PP. 141A. May 15-19, 2001 [Abstract : 49AJH2001.pdf]

Tonomoto, Mariko; Maruyama, Chizuko; Imamura, Kayoko; Harada, Miho; Egami, Satoko; Baba, Naoko; Ayaori, Makoto; Inakuma, Takahiro; Ishikawa, Toshitsugu; Oshima, Shunji; Suzukawa, Michio - Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, 112-8681, Japan - Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. Journal of Nutritional Science and Vitaminology VOL.47 N.3 June, 2001 PP. 213-221

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Gianetti J, Pedrinelli R, Petrucci R, Lazzerini G, De Caterina M, Bellomo G, De Caterina R. C. N. R. Institute of Clinical Physiology, University of Pisa, Pisa, Italy. Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. Am Heart J 2002 Mar;143(3):467-74 [File : 58AmHeartJ2002.pdf]

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Tero Hirvoven; Jarmo Virtamo ; Pasi Korhonen ; Demetrius Albanes ; Pirjo Pietinen. Intake of Flavonoids , carotenoids ,Vitamin C, Vitamin E and Risk of Stroke in Male Smokers. Journal of the American Heart Association. Stroke 2000; 31 ; 2301-2306 . [File : 68Stroke2000.pdf]

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Bansal P, Gupta SK, Ojha SK, Nandave M, Mittal R, Kumari S, Arya DS. - Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. Cardioprotective effect of lycopene in the experimental model of myocardial ischemia-reperfusion injury. Mol Cell Biochem. 2006 Apr 7

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Engelhard YN, Gazer B, Paran E. - Hypertension Unit, Faculty of Health Sciences, Soroka University Medical Centre, Ben Gurion, University of the Negev, 84101 Beer Sheva, Israel. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: double-blind, placebo-controlled pilot study. Am Heart J. 2006 Jan;151(1):100. [File : 72AmHeartJ2006.pdf]

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Karimi G, Ramezani M, Abdi A. Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity. Phytother Res. 2005 Oct;19(10):912-4. Copyright (c) 2005 John Wiley & Sons, Ltd.

Hsiao G, Wang Y, Tzu NH, Fong TH, Shen MY, Lin KH, Chou DS, Sheu JR. - Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med. 2005 Oct;146(4):216-26

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Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S. - Department of Biochemistry, College of Veterinary Medicine, Faculty of Veterinary, Firat (Euphrates) University, Turkey. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology. 2006 Feb 1;218(2-3):164-71. Epub 2005 Dec 1

Sesso HD, Buring JE, Norkus EP, Gaziano JM. - Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr. 2005 May;81(5):990-7. [Full text ; file : 77AmJClinNutr2005.pdf]

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Sesso HD. - Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School and Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, USA. Carotenoids and cardiovascular disease: what research gaps remain? Curr Opin Lipidol. 2006 Feb;17(1):11-16.

Sesso HD, Buring JE, Norkus EP, Gaziano JM. - Division of Preventive Medicine, Department of Medicine, Brigham and Women's , Hospital and Harvard Medical School, Boston, MA 02215, USA. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr. 2004 Jan; 79(1): 47- 53. [File : 79 AJCN 2004.pdf

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Rissanen TH, Voutilainen S, Nyyssonen K, Salonen R, Kaplan GA, Salonen JT. Research Institute of Public Health (THR, SV, KN, RS, and JTS) and the Department of Public Health and General Practice (THR and JTS), University of Kuopio, Kuopio, Finland. Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2003 Jan;77(1):133-8 [File : 80AmJClinNutr2003.pdf]

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Ahuja KD, Pittaway JK, Ball MJ. - School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia. Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation. Nutrition. 2006 Jan 12;

Chang CY, Chen JY, Ke D, Hu ML. Department of Neurology, Chi-Mei Foundation Hospital, Tainan, Taiwan, ROC. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition. 2005 Oct;21(10):987-93

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M.A.Newaz; N.N.A. Nawal– Faculty of Medicine Kuala Lampur - Malysia – Effect of alfa–tocopherol on lipid peroxidation and total antioxidant status in spontaneously hyeprtensive rats. The American Journal of Hypertension . AJH 1998 ; 11:1480-1485. [File : 91AJH1998.pdf]

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Hadley CW, Clinton SK, Schwartz SJ. - The Department of Food Science and Technology, The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA. -The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J Nutr 2003 Mar;133(3):727-32 [File : 97 JNutr2003.pdf]

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Jonasson L, Wikby A, Olsson AG. - Department of Cardiology, Heart Center, University Hospital, S-581 85 Linkoping, Sweden. Low serum beta-carotene reflects immune activation in patients with coronary artery disease. Nutr Metab Cardiovasc Dis. 2003 Jun;13(3):120-5

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Kaumudi J Joshipura; Frank B. Hu; JoAnn E. Manson; Meier J. Stampfer ; Eric B. Rimm ; Frank E. Spelzen; Graham Colditz; Alberto Ascherio; Bernard Rosner ; Donna Spiegelmam ; Walter C. Willet. The effect of Fruits and Vegetable intake on Risk for Coronary Heart Disease. Ann. Intern. Med. 2001; 134: 1106-1114. [File : 108AIM2001.pdf

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H.D. Sesso, Simin Liu, J.Michael Graziano and J.E. Buring. Dietary Lycopene, Tomato based product and cardiovascular disease in women. The Journal of Nutrition. J. Nutr 133 : 2336-2341 , 2003 [file : 112JNutr2003.pdf]

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Paran Esther; Engelhard Yehiel, Inbal Hazan-Hallevy, Yoav Sharoni, Joseph Levy - Hypertension Unit, Soroka University medical Center, Beer Sheva, Israel - Effect of standardized tomato extract on blood pressure, endothelial function and plasma Lycopene level in treated hypertensive patients. American Journal of Hypertension Vol. 18 No. 5 Part 2- May 2005 [Abstract : 114AJH2005.pdf

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Lu Wang, J. Michael Gaziano, Edward P. Norkus, Julie E Buring, and Howard D. Sesso- Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women - Am J Clin Nutr. 2008 September ; 88(3): 747–754. [File 138 AJCN 2008.pdf]

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Peter W. de Leeuw & Aalt Bast - Tomato Extract for Hypertension? Editorial to “The Effects of Natural Antioxidants from Tomato Extract in Treated but Uncontrolled Hypertensive Patients” by E. Paran et al. - Cardiovasc Drugs Ther (2009) 23:107–108 [File 139 CDT 2009.pdf]

Hussein O, Frydman G, Frim H, Aviram M. Lipid Research Laboratory, Government Rebecca Sieff Hospital, P.O. Box 1008, 13100, Safed, Israel - Reduced susceptibility of low density lipoprotein to lipid peroxidation after cholestyramine treatment in heterozygous familial hypercholesterolemic children. Pathophysiology 2001 Aug;8(1):21-28

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Frank B Hu, Eric B Rimm, Meir J Stampfer, Alberto Ascherio, Donna Spiegelman, and Walter C Willett - Prospective study of major dietary patterns and risk of coronary heart disease in men1–3 -. Am J Clin Nutr 2000;72:912–21. [File 141 AJCN 2000.pdf

Heart supplements
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Organic lycopene the perfect Italian antioxidant
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Made in Italy

CARDIOVASCULAR RISK - PROTECTING YOUR HEALTH
Cardiovascular and coronary heart diseases are the main causes of early death in many developed countries across the world. They are caused by the formation and the development of an atherosclerotic plaque on the internal walls of the arteries. This process is due to the oxidisation of low density lipoproteins (LDL), which produces lipidic deposits (atheromata). LDL is the main carrier of cholesterol into the blood stream. Oxidized LDL (LDLox) are not able to play correctly their role and are removed and destroyed by macrophages. When a LDLox excess occurs, the macrophages become larger, change their aspect and accumulate on the walls of the arteries. The gradual build up of these deposits causes the arteries to narrow and harden, restricting the flow of oxygenated blood to the heart muscle. This can cause angina and, if a coronary artery becomes completely blocked, it can cause permanent damage to the heart muscle or heart attack.

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LYCOMPLETE - LYCOPENE EXTRACTED FROM ORGANIC TOMATOES BY SUPERCRITICAL CO2 FREE OF CHEMICAL SOLVENTS

ORGANIC LYCOPENE TO THE FOOD SUPPLEMENTS INDUSTRY BY PIERRE GROUP - THE PERFECT ANTIOXIDANT MADE IN ITALY

LYCOPENE SOURCES Lycopene is a carotenoid, a group of compounds present in many fresh fruits and vegetables. There are more than 750 types of carotenoids in nature; however, only 20 of these have been found in human blood and tissues. The carotenoid most often present in human blood is lycopene ,followed by b -carotene, lutein and zeaxanthin.

 RED RIPE TOMATOES THE MAIN SOURCE OF LYCOPENE and their derivatives are the main natural source of lycopene giving approximately 85% of all lycopene in the human body. The amount of lycopene in tomatoes depends the quality of fruit, the environment and cultivation procedures. Usually, the content of lycopene in red-ripe tomatoes is 30-80 mg/kg of fresh product, but it could be more than 150-300 mg/kg in some selected species obtained by traditional hybridization techniques.
PROPERTIES OF ORGANIC LYCOPENE the organic lycopene has a very strong antioxidant power, as antioxidant contrasts the destructive action of free radicals in the human body (which are seriously dangerous for the cells and tissues) protects and prevents against several diseases... SEE FULL INFORMATION

Health Prostate Dietary

Lycodeep skin care supplement

Lycomplete heart supplement

Lycosport athlete supplements

Lycocor for Italian market

Vitilicaps for Santo Domingo market

Naturmio women for Italian market

Lycofor (eyes optic) for Italian market

We offer our full dietary, food and health care supplements manufacturing knowledge plus our engineering capabilities to create, design, produce new supplement products, in Private label, for manufacturers and distributors.

Naturmio Health Prostate for Italy

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